An insilico study of selected mannose derivatives against UropathogenicEscherichia colitargeting fimH adhesin protein

Urinary tract infections (UTI) caused primarily by uropathogenic Escherichia coli (UPEC) are indeed an extremely contagious disease that affects people all over the world. FimH is a major virulence component in UTI pathogenesis, and inhibiting function can be efficient means to disarm UPEC bacteria, as well crucial target development of non-antibiotic mediated treatment options. The goal this study was identify phytochemicals Cranberry Bearberry plant parts assess their pharmacological characteristics. A computational methodology used predict characteristics such substances. Compounds with pharmacophores comparable those known fimH inhibitors were chosen. Following that, additional research carried out drug similarity, inhibitory potential, IC50 values.Thus, present reports few novel fimHinhibitors derived from selected plant’sphytochemicals, significant owing therapeutic implication therapy for UTI.International Journal Human Health Sciences Vol. 06 No. 04 Oct’22 Page: 420-431